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Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib
BACKGROUND: XIAP (X-linked inhibitor of apoptosis protein) is an anti-apoptotic protein exerting its activity by binding and suppressing caspases. As XIAP is overexpressed in several tumours, in which it apparently contributes to chemoresistance, and because its activity in vivo is antagonised by se...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2883696/ https://ncbi.nlm.nih.gov/pubmed/20461078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605687 |
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