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Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity
Smac mimetics (SMs) comprise a class of small molecules that target members of the inhibitor of apoptosis family of pro-survival proteins, whose expression in cancer cells hinders the action of conventional chemotherapeutics. Herein, we describe the activity of SM83, a newly synthesised dimeric SM,...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3847325/ https://ncbi.nlm.nih.gov/pubmed/24232096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.449 |
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