Recognition of Smac-mimetic compounds by the BIR domain of cIAP1

Inhibitor of apoptosis proteins (IAPs) are negative regulators of apoptosis. As IAPs are overexpressed in many tumors, where they confer chemoresistance, small molecules inactivating IAPs have been proposed as anticancer agents. Accordingly, a number of IAP-binding pro-apoptotic compounds that mimic...

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Hauptverfasser: Cossu, Federica, Malvezzi, Francesca, Canevari, Giulia, Mastrangelo, Eloise, Lecis, Daniele, Delia, Domenico, Seneci, Pierfausto, Scolastico, Carlo, Bolognesi, Martino, Milani, Mario
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009409/
https://ncbi.nlm.nih.gov/pubmed/20954235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.523
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