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Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2
The inhibitors of apoptosis (IAP) proteins cIAP1 and cIAP2 have recently emerged as key ubiquitin-E3 ligases regulating innate immunity and cell survival. Much of our knowledge of these IAPs stems from studies using pharmacological inhibitors of IAPs, dubbed Smac mimetics (SMs). Although SMs stimula...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3172091/ https://ncbi.nlm.nih.gov/pubmed/21331077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.10 |
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