Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2

The inhibitors of apoptosis (IAP) proteins cIAP1 and cIAP2 have recently emerged as key ubiquitin-E3 ligases regulating innate immunity and cell survival. Much of our knowledge of these IAPs stems from studies using pharmacological inhibitors of IAPs, dubbed Smac mimetics (SMs). Although SMs stimula...

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Main Authors: Darding, M, Feltham, R, Tenev, T, Bianchi, K, Benetatos, C, Silke, J, Meier, P
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
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Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172091/
https://ncbi.nlm.nih.gov/pubmed/21331077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.10
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