Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression

Smac mimetics target cancer cells in a TNFα-dependent manner, partly via proteasome degradation of cellular inhibitor of apoptosis 1 (cIAP1) and cIAP2. Degradation of cIAPs triggers the release of receptor interacting protein kinase (RIPK1) from TNF receptor I (TNFR1) to form a caspase-8 activating...

Full description

Saved in:
Bibliographic Details
Main Authors: Petersen, Sean L., Peyton, Michael, Minna, John D., Wang, Xiaodong
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900705/
https://ncbi.nlm.nih.gov/pubmed/20547836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005667107
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items