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Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression
Smac mimetics target cancer cells in a TNFα-dependent manner, partly via proteasome degradation of cellular inhibitor of apoptosis 1 (cIAP1) and cIAP2. Degradation of cIAPs triggers the release of receptor interacting protein kinase (RIPK1) from TNF receptor I (TNFR1) to form a caspase-8 activating...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900705/ https://ncbi.nlm.nih.gov/pubmed/20547836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005667107 |
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