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USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics
Given their crucial role in apoptosis suppression, inhibitor of apoptosis proteins (IAPs) have recently become attractive targets for cancer therapy. Here, we report that cellular IAP2 (cIAP2) is specifically stabilized in several cancer cell lines, leading to resistance to Smac mimetics, such as BV...
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| Publié dans: | Cell Death Differ |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4532773/ https://ncbi.nlm.nih.gov/pubmed/25613375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.234 |
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