ロード中...

USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics

Given their crucial role in apoptosis suppression, inhibitor of apoptosis proteins (IAPs) have recently become attractive targets for cancer therapy. Here, we report that cellular IAP2 (cIAP2) is specifically stabilized in several cancer cell lines, leading to resistance to Smac mimetics, such as BV...

詳細記述

保存先:
書誌詳細
出版年:Cell Death Differ
主要な著者: Lee, E-W, Seong, D, Seo, J, Jeong, M, Lee, H-K, Song, J
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532773/
https://ncbi.nlm.nih.gov/pubmed/25613375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.234
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!