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USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics
Given their crucial role in apoptosis suppression, inhibitor of apoptosis proteins (IAPs) have recently become attractive targets for cancer therapy. Here, we report that cellular IAP2 (cIAP2) is specifically stabilized in several cancer cell lines, leading to resistance to Smac mimetics, such as BV...
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| 出版年: | Cell Death Differ |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4532773/ https://ncbi.nlm.nih.gov/pubmed/25613375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.234 |
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