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USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics
Given their crucial role in apoptosis suppression, inhibitor of apoptosis proteins (IAPs) have recently become attractive targets for cancer therapy. Here, we report that cellular IAP2 (cIAP2) is specifically stabilized in several cancer cell lines, leading to resistance to Smac mimetics, such as BV...
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| Publicado no: | Cell Death Differ |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4532773/ https://ncbi.nlm.nih.gov/pubmed/25613375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.234 |
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