Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization

The inhibitor of apoptosis (IAP) proteins are important ubiquitin E3 ligases that regulate cell survival and oncogenesis. The cIAP1 and cIAP2 paralogs bear three N-terminal baculoviral IAP repeat (BIR) domains and a C-terminal E3 ligase RING domain. IAP antagonist compounds, also known as Smac mimet...

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Main Authors: Feltham, Rebecca, Bettjeman, Bodhi, Budhidarmo, Rhesa, Mace, Peter D., Shirley, Sarah, Condon, Stephen M., Chunduru, Srinivas K., McKinlay, Mark A., Vaux, David L., Silke, John, Day, Catherine L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089546/
https://ncbi.nlm.nih.gov/pubmed/21393245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.222919
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