Structure‐Activity Relationship of NF023 Derivatives Binding to XIAP‐BIR1

Inhibitors of Apoptosis Proteins (IAPs) are conserved E3‐ligases that ubiquitylate substrates to prevent apoptosis and activate the NF‐kB survival pathway, often deregulated in cancer. IAPs‐mediated regulation of NF‐kB signaling is based on the formation of protein complexes by their type‐I BIR doma...

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Pubblicato in:ChemistryOpen
Autori principali: Sorrentino, Luca, Cossu, Federica, Milani, Mario, Malkoc, Bilge, Huang, Wen‐Chieh, Tsay, Shwu‐Chen, Ru Hwu, Jih, Mastrangelo, Eloise
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Full Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6460348/
https://ncbi.nlm.nih.gov/pubmed/31011505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201900059
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