Structural Bases of Norovirus RNA Dependent RNA Polymerase Inhibition by Novel Suramin-Related Compounds

Noroviruses (NV) are +ssRNA viruses responsible for severe gastroenteritis; no effective vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp). Despite significant in vitro activities versus several pharma...

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Bibliografiska uppgifter
Huvudupphovsmän: Croci, Romina, Pezzullo, Margherita, Tarantino, Delia, Milani, Mario, Tsay, Shwu-Chen, Sureshbabu, Radhakrishnan, Tsai, Yi-Jin, Mastrangelo, Eloise, Rohayem, Jacques, Bolognesi, Martino, Hwu, Jih Ru
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951423/
https://ncbi.nlm.nih.gov/pubmed/24622391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091765
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