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Structure‐Activity Relationship of NF023 Derivatives Binding to XIAP‐BIR1
Inhibitors of Apoptosis Proteins (IAPs) are conserved E3‐ligases that ubiquitylate substrates to prevent apoptosis and activate the NF‐kB survival pathway, often deregulated in cancer. IAPs‐mediated regulation of NF‐kB signaling is based on the formation of protein complexes by their type‐I BIR doma...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | ChemistryOpen |
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| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
John Wiley and Sons Inc.
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6460348/ https://ncbi.nlm.nih.gov/pubmed/31011505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201900059 |
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