Colorectal carcinomas containing hypermethylated MLH1 promoter and wild type BRAF/KRAS are enriched for targetable kinase fusions

Kinase fusions are rare and poorly characterized in colorectal carcinoma (CRC), yet they present unique opportunities for targeted therapy. In this study, we characterized kinase fusions from patients with advanced CRC who had MSK-IMPACT testing of their tumors between January 2014 and June 2018. Pa...

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Detalles Bibliográficos
Publicado en:Cancer Res
Main Authors: Cocco, Emiliano, Benhamida, Jamal, Middha, Sumit, Zehir, Ahmet, Mullaney, Kerry, Shia, Jinru, Yaeger, Rona, Zhang, Liying, Wong, Donna, Villafania, Liliana, Nafa, Khedoudja, Scaltriti, Maurizio, Drilon, Alexander, Saltz, Leonard, Schram, Alison M., Stadler, Zsofia K., Hyman, David M., Benayed, Ryma, Ladanyi, Marc, Hechtman, Jaclyn F.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420871/
https://ncbi.nlm.nih.gov/pubmed/30643016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3126
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