Colorectal carcinomas containing hypermethylated MLH1 promoter and wild type BRAF/KRAS are enriched for targetable kinase fusions

Kinase fusions are rare and poorly characterized in colorectal carcinoma (CRC), yet they present unique opportunities for targeted therapy. In this study, we characterized kinase fusions from patients with advanced CRC who had MSK-IMPACT testing of their tumors between January 2014 and June 2018. Pa...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cancer Res
Hlavní autoři: Cocco, Emiliano, Benhamida, Jamal, Middha, Sumit, Zehir, Ahmet, Mullaney, Kerry, Shia, Jinru, Yaeger, Rona, Zhang, Liying, Wong, Donna, Villafania, Liliana, Nafa, Khedoudja, Scaltriti, Maurizio, Drilon, Alexander, Saltz, Leonard, Schram, Alison M., Stadler, Zsofia K., Hyman, David M., Benayed, Ryma, Ladanyi, Marc, Hechtman, Jaclyn F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420871/
https://ncbi.nlm.nih.gov/pubmed/30643016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3126
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky