Colorectal carcinomas containing hypermethylated MLH1 promoter and wild type BRAF/KRAS are enriched for targetable kinase fusions

Kinase fusions are rare and poorly characterized in colorectal carcinoma (CRC), yet they present unique opportunities for targeted therapy. In this study, we characterized kinase fusions from patients with advanced CRC who had MSK-IMPACT testing of their tumors between January 2014 and June 2018. Pa...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Cocco, Emiliano, Benhamida, Jamal, Middha, Sumit, Zehir, Ahmet, Mullaney, Kerry, Shia, Jinru, Yaeger, Rona, Zhang, Liying, Wong, Donna, Villafania, Liliana, Nafa, Khedoudja, Scaltriti, Maurizio, Drilon, Alexander, Saltz, Leonard, Schram, Alison M., Stadler, Zsofia K., Hyman, David M., Benayed, Ryma, Ladanyi, Marc, Hechtman, Jaclyn F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420871/
https://ncbi.nlm.nih.gov/pubmed/30643016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3126
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