Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and somatic MSH2 mutations

Microsatellite instability (MSI), a well-established driver pathway in colorectal carcinogenesis, can develop in both sporadic and hereditary conditions via different molecular alterations in the DNA mismatch repair (MMR) genes. MMR protein immunohistochemistry (IHC) is currently widely used for the...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Fam Cancer
Autors principals: Wang, Tao, Stadler, Zsofia K., Zhang, Liying, Weiser, Martin R., Basturk, Olca, Hechtman, Jaclyn F., Vakiani, Efsevia, Saltz, Lenard B., Klimstra, David S., Shia, Jinru
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908711/
https://ncbi.nlm.nih.gov/pubmed/28819720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-017-0031-9
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars