Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and somatic MSH2 mutations

Microsatellite instability (MSI), a well-established driver pathway in colorectal carcinogenesis, can develop in both sporadic and hereditary conditions via different molecular alterations in the DNA mismatch repair (MMR) genes. MMR protein immunohistochemistry (IHC) is currently widely used for the...

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Publicado en:Fam Cancer
Main Authors: Wang, Tao, Stadler, Zsofia K., Zhang, Liying, Weiser, Martin R., Basturk, Olca, Hechtman, Jaclyn F., Vakiani, Efsevia, Saltz, Lenard B., Klimstra, David S., Shia, Jinru
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908711/
https://ncbi.nlm.nih.gov/pubmed/28819720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-017-0031-9
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