Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and somatic MSH2 mutations

Microsatellite instability (MSI), a well-established driver pathway in colorectal carcinogenesis, can develop in both sporadic and hereditary conditions via different molecular alterations in the DNA mismatch repair (MMR) genes. MMR protein immunohistochemistry (IHC) is currently widely used for the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Fam Cancer
Prif Awduron: Wang, Tao, Stadler, Zsofia K., Zhang, Liying, Weiser, Martin R., Basturk, Olca, Hechtman, Jaclyn F., Vakiani, Efsevia, Saltz, Lenard B., Klimstra, David S., Shia, Jinru
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908711/
https://ncbi.nlm.nih.gov/pubmed/28819720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-017-0031-9
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