Colorectal carcinomas containing hypermethylated MLH1 promoter and wild type BRAF/KRAS are enriched for targetable kinase fusions

Kinase fusions are rare and poorly characterized in colorectal carcinoma (CRC), yet they present unique opportunities for targeted therapy. In this study, we characterized kinase fusions from patients with advanced CRC who had MSK-IMPACT testing of their tumors between January 2014 and June 2018. Pa...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Cocco, Emiliano, Benhamida, Jamal, Middha, Sumit, Zehir, Ahmet, Mullaney, Kerry, Shia, Jinru, Yaeger, Rona, Zhang, Liying, Wong, Donna, Villafania, Liliana, Nafa, Khedoudja, Scaltriti, Maurizio, Drilon, Alexander, Saltz, Leonard, Schram, Alison M., Stadler, Zsofia K., Hyman, David M., Benayed, Ryma, Ladanyi, Marc, Hechtman, Jaclyn F.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420871/
https://ncbi.nlm.nih.gov/pubmed/30643016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3126
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