Reliable Clinical MLH1 Promoter Hypermethylation Assessment Using a High-Throughput Genome-Wide Methylation Array Platform

Clinical testing for MLH1 promoter hypermethylation status is important in the workup of patients with MLH1-deficient colorectal and uterine carcinomas when evaluating patients for Lynch syndrome. Current assays use single gene–based methods to assess promoter hypermethylation. Herein, we describe t...

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Publicat a:J Mol Diagn
Autors principals: Benhamida, Jamal K., Hechtman, Jaclyn F., Nafa, Khedoudja, Villafania, Liliana, Sadowska, Justyna, Wang, Jiajing, Wong, Donna, Zehir, Ahmet, Zhang, Liying, Bale, Tejus, Arcila, Maria E., Ladanyi, Marc
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7103764/
https://ncbi.nlm.nih.gov/pubmed/31881335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2019.11.005
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