Novel Oncogene and Tumor Suppressor Mutations in KIT and PDGFRA Wild Type Gastrointestinal Stromal Tumors Revealed by Next Generation Sequencing

Among gastrointestinal stromal tumors (GISTs) of 10–15% are negative for KIT and PDGFRA, and most of these cases are SDH deficient. Recent studies have provided data on additional molecular alterations such as KRAS in KIT mutant GISTs. We aimed to assess the frequency and spectrum of somatic mutatio...

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Veröffentlicht in:Genes Chromosomes Cancer
Hauptverfasser: Hechtman, Jaclyn Frances, Zehir, Ahmet, Mitchell, Talia, Borsu, Laetitia, Singer, Samuel, Tap, William, Oultache, Alifya, Ladanyi, Marc, Nafa, Khedoudja
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452627/
https://ncbi.nlm.nih.gov/pubmed/25427437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22230
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