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Novel Oncogene and Tumor Suppressor Mutations in KIT and PDGFRA Wild Type Gastrointestinal Stromal Tumors Revealed by Next Generation Sequencing

Among gastrointestinal stromal tumors (GISTs) of 10–15% are negative for KIT and PDGFRA, and most of these cases are SDH deficient. Recent studies have provided data on additional molecular alterations such as KRAS in KIT mutant GISTs. We aimed to assess the frequency and spectrum of somatic mutatio...

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Publicat a:Genes Chromosomes Cancer
Autors principals: Hechtman, Jaclyn Frances, Zehir, Ahmet, Mitchell, Talia, Borsu, Laetitia, Singer, Samuel, Tap, William, Oultache, Alifya, Ladanyi, Marc, Nafa, Khedoudja
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452627/
https://ncbi.nlm.nih.gov/pubmed/25427437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22230
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