Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning

[Image: see text] Potent covalent inhibitors of Bruton’s tyrosine kinase (BTK) based on an aminopyrazole carboxamide scaffold have been identified. Compared to acrylamide-based covalent reactive groups leading to irreversible protein adducts, cyanamide-based reversible-covalent inhibitors provided t...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Schnute, Mark E., Benoit, Stephen E., Buchler, Ingrid P., Caspers, Nicole, Grapperhaus, Margaret L., Han, Seungil, Hotchandani, Rajeev, Huang, Nelson, Hughes, Robert O., Juba, Brian M., Kim, Kyung-Hee, Liu, Erica, McCarthy, Erin, Messing, Dean, Miyashiro, Joy S., Mohan, Shashi, O’Connell, Thomas N., Ohren, Jeffrey F., Parikh, Mihir D., Schmidt, Michelle, Selness, Shaun R., Springer, John R., Thanabal, Venkataraman, Trujillo, John I., Walker, Daniel P., Wan, Zhao-Kui, Withka, Jane M., Wittwer, Arthur J., Wood, Nancy L., Xing, Li, Zapf, Christoph W., Douhan, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331194/
https://ncbi.nlm.nih.gov/pubmed/30655951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00461
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