SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

[Image: see text] We previously discovered compounds based on a 5-aminopyrazole-4-carboxamide scaffold to be potent and selective inhibitors of CDPK1 from T. gondii. The current work, through structure–activity relationship studies, led to the discovery of compounds (34 and 35) with improved charact...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Huang, Wenlin, Ojo, Kayode K., Zhang, Zhongsheng, Rivas, Kasey, Vidadala, Rama Subba Rao, Scheele, Suzanne, DeRocher, Amy E., Choi, Ryan, Hulverson, Matthew A., Barrett, Lynn K., Bruzual, Igor, Siddaramaiah, Latha Kallur, Kerchner, Keshia M., Kurnick, Matthew D., Freiberg, Gail M., Kempf, Dale, Hol, Wim G. J., Merritt, Ethan A., Neckermann, Georg, de Hostos, Eugenio L., Isoherranen, Nina, Maly, Dustin J., Parsons, Marilyn, Doggett, J. Stone, Van Voorhis, Wesley C., Fan, Erkang
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677665/
https://ncbi.nlm.nih.gov/pubmed/26693272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00319
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