Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

[Image: see text] 5-Aminopyrazole-4-carboxamide was used as an alternative scaffold to substitute for the pyrazolopyrimidine of a known “bumped kinase inhibitor” to create selective inhibitors of calcium-dependent protein kinase-1 from both Toxoplasma gondii and Cryptosporidium parvum. Compounds wit...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Zhang, Zhongsheng, Ojo, Kayode K., Vidadala, RamaSubbaRao, Huang, Wenlin, Geiger, Jennifer A., Scheele, Suzanne, Choi, Ryan, Reid, Molly C., Keyloun, Katelyn R., Rivas, Kasey, Kallur Siddaramaiah, Latha, Comess, Kenneth M., Robinson, Kenneth P., Merta, Philip J., Kifle, Lemma, Hol, Wim G. J., Parsons, Marilyn, Merritt, Ethan A., Maly, Dustin J., Verlinde, Christophe L. M. J., Van Voorhis, Wesley C., Fan, Erkang
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2013
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908674/
https://ncbi.nlm.nih.gov/pubmed/24494061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400315s
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια