Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

[Image: see text] 5-Aminopyrazole-4-carboxamide was used as an alternative scaffold to substitute for the pyrazolopyrimidine of a known “bumped kinase inhibitor” to create selective inhibitors of calcium-dependent protein kinase-1 from both Toxoplasma gondii and Cryptosporidium parvum. Compounds wit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Zhang, Zhongsheng, Ojo, Kayode K., Vidadala, RamaSubbaRao, Huang, Wenlin, Geiger, Jennifer A., Scheele, Suzanne, Choi, Ryan, Reid, Molly C., Keyloun, Katelyn R., Rivas, Kasey, Kallur Siddaramaiah, Latha, Comess, Kenneth M., Robinson, Kenneth P., Merta, Philip J., Kifle, Lemma, Hol, Wim G. J., Parsons, Marilyn, Merritt, Ethan A., Maly, Dustin J., Verlinde, Christophe L. M. J., Van Voorhis, Wesley C., Fan, Erkang
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908674/
https://ncbi.nlm.nih.gov/pubmed/24494061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400315s
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados