Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

[Image: see text] 5-Aminopyrazole-4-carboxamide was used as an alternative scaffold to substitute for the pyrazolopyrimidine of a known “bumped kinase inhibitor” to create selective inhibitors of calcium-dependent protein kinase-1 from both Toxoplasma gondii and Cryptosporidium parvum. Compounds wit...

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Bibliografski detalji
Glavni autori: Zhang, Zhongsheng, Ojo, Kayode K., Vidadala, RamaSubbaRao, Huang, Wenlin, Geiger, Jennifer A., Scheele, Suzanne, Choi, Ryan, Reid, Molly C., Keyloun, Katelyn R., Rivas, Kasey, Kallur Siddaramaiah, Latha, Comess, Kenneth M., Robinson, Kenneth P., Merta, Philip J., Kifle, Lemma, Hol, Wim G. J., Parsons, Marilyn, Merritt, Ethan A., Maly, Dustin J., Verlinde, Christophe L. M. J., Van Voorhis, Wesley C., Fan, Erkang
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908674/
https://ncbi.nlm.nih.gov/pubmed/24494061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400315s
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