Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

[Image: see text] 5-Aminopyrazole-4-carboxamide was used as an alternative scaffold to substitute for the pyrazolopyrimidine of a known “bumped kinase inhibitor” to create selective inhibitors of calcium-dependent protein kinase-1 from both Toxoplasma gondii and Cryptosporidium parvum. Compounds wit...

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Main Authors: Zhang, Zhongsheng, Ojo, Kayode K., Vidadala, RamaSubbaRao, Huang, Wenlin, Geiger, Jennifer A., Scheele, Suzanne, Choi, Ryan, Reid, Molly C., Keyloun, Katelyn R., Rivas, Kasey, Kallur Siddaramaiah, Latha, Comess, Kenneth M., Robinson, Kenneth P., Merta, Philip J., Kifle, Lemma, Hol, Wim G. J., Parsons, Marilyn, Merritt, Ethan A., Maly, Dustin J., Verlinde, Christophe L. M. J., Van Voorhis, Wesley C., Fan, Erkang
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908674/
https://ncbi.nlm.nih.gov/pubmed/24494061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400315s
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