5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum

Cryptosporidium parvum calcium-dependent protein kinase 1 (CpCDPK1) is a promising target for drug development against cryptosporidiosis. We report a series of low-nanomolar CpCDPK1 5-aminopyrazole-4-carboxamide (AC) scaffold inhibitors that also potently inhibit C. parvum growth in vitro. Correlati...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Huang, Wenlin, Choi, Ryan, Hulverson, Matthew A., Zhang, Zhongsheng, McCloskey, Molly C., Schaefer, Deborah A., Whitman, Grant R., Barrett, Lynn K., Vidadala, Rama Subba Rao, Riggs, Michael W., Maly, Dustin J., Van Voorhis, Wesley C., Ojo, Kayode K., Fan, Erkang
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2017
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527629/
https://ncbi.nlm.nih.gov/pubmed/28533246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00020-17
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