5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum

Cryptosporidium parvum calcium-dependent protein kinase 1 (CpCDPK1) is a promising target for drug development against cryptosporidiosis. We report a series of low-nanomolar CpCDPK1 5-aminopyrazole-4-carboxamide (AC) scaffold inhibitors that also potently inhibit C. parvum growth in vitro. Correlati...

詳細記述

保存先:
書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Huang, Wenlin, Choi, Ryan, Hulverson, Matthew A., Zhang, Zhongsheng, McCloskey, Molly C., Schaefer, Deborah A., Whitman, Grant R., Barrett, Lynn K., Vidadala, Rama Subba Rao, Riggs, Michael W., Maly, Dustin J., Van Voorhis, Wesley C., Ojo, Kayode K., Fan, Erkang
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2017
主題:
Experimental Therapeutics
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527629/
https://ncbi.nlm.nih.gov/pubmed/28533246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00020-17
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