5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum

Cryptosporidium parvum calcium-dependent protein kinase 1 (CpCDPK1) is a promising target for drug development against cryptosporidiosis. We report a series of low-nanomolar CpCDPK1 5-aminopyrazole-4-carboxamide (AC) scaffold inhibitors that also potently inhibit C. parvum growth in vitro. Correlati...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Huang, Wenlin, Choi, Ryan, Hulverson, Matthew A., Zhang, Zhongsheng, McCloskey, Molly C., Schaefer, Deborah A., Whitman, Grant R., Barrett, Lynn K., Vidadala, Rama Subba Rao, Riggs, Michael W., Maly, Dustin J., Van Voorhis, Wesley C., Ojo, Kayode K., Fan, Erkang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527629/
https://ncbi.nlm.nih.gov/pubmed/28533246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00020-17
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