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5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum

Cryptosporidium parvum calcium-dependent protein kinase 1 (CpCDPK1) is a promising target for drug development against cryptosporidiosis. We report a series of low-nanomolar CpCDPK1 5-aminopyrazole-4-carboxamide (AC) scaffold inhibitors that also potently inhibit C. parvum growth in vitro. Correlati...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Huang, Wenlin, Choi, Ryan, Hulverson, Matthew A., Zhang, Zhongsheng, McCloskey, Molly C., Schaefer, Deborah A., Whitman, Grant R., Barrett, Lynn K., Vidadala, Rama Subba Rao, Riggs, Michael W., Maly, Dustin J., Van Voorhis, Wesley C., Ojo, Kayode K., Fan, Erkang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527629/
https://ncbi.nlm.nih.gov/pubmed/28533246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00020-17
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