5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents

Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) is essential for the exflagellation of male gametocytes. Inhibition of PfCDPK4 is an effective way of blocking the transmission of malaria by mosquitoes. A series of 5-aminopyrazole-4-carboxamide analogues are demonstrated to be pote...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Huang, Wenlin, Hulverson, Matthew A., Zhang, Zhongsheng, Choi, Ryan, Hart, Kevin J., Kennedy, Mark, RaoVidadala, Rama Subba, Maly, Dustin J., Van Voorhis, Wesley C., Lindner, Scott E., Fan, Erkang, Ojo, Kayode K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159281/
https://ncbi.nlm.nih.gov/pubmed/27780638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.10.014
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