Development of 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors for Cryptosporidiosis therapy

Cryptosporidium is a leading cause of pediatric diarrhea worldwide. Currently there is neither a vaccine nor a consistently effective drug available for this disease. Selective 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors (BKIs) are effective in both in vitro and in vivo models of Cr...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Huang, Wenlin, Hulverson, Matthew A., Choi, Ryan, Arnold, Samuel L.M., Zhang, Zhongsheng, McCloskey, Molly C., Whitman, Grant R., Hackman, Robert C., Rivas, Kasey L., Barrett, Lynn K., Ojo, Kayode K., Van Voorhis, Wesley C., Fan, Erkang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559944/
https://ncbi.nlm.nih.gov/pubmed/30830766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00069
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