Development of 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors for Cryptosporidiosis therapy

Cryptosporidium is a leading cause of pediatric diarrhea worldwide. Currently there is neither a vaccine nor a consistently effective drug available for this disease. Selective 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors (BKIs) are effective in both in vitro and in vivo models of Cr...

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Publicado en:J Med Chem
Main Authors: Huang, Wenlin, Hulverson, Matthew A., Choi, Ryan, Arnold, Samuel L.M., Zhang, Zhongsheng, McCloskey, Molly C., Whitman, Grant R., Hackman, Robert C., Rivas, Kasey L., Barrett, Lynn K., Ojo, Kayode K., Van Voorhis, Wesley C., Fan, Erkang
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559944/
https://ncbi.nlm.nih.gov/pubmed/30830766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00069
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