Development of 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors for Cryptosporidiosis therapy

Cryptosporidium is a leading cause of pediatric diarrhea worldwide. Currently there is neither a vaccine nor a consistently effective drug available for this disease. Selective 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors (BKIs) are effective in both in vitro and in vivo models of Cr...

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Pubblicato in:J Med Chem
Autori principali: Huang, Wenlin, Hulverson, Matthew A., Choi, Ryan, Arnold, Samuel L.M., Zhang, Zhongsheng, McCloskey, Molly C., Whitman, Grant R., Hackman, Robert C., Rivas, Kasey L., Barrett, Lynn K., Ojo, Kayode K., Van Voorhis, Wesley C., Fan, Erkang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559944/
https://ncbi.nlm.nih.gov/pubmed/30830766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00069
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