Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis

Bumped kinase inhibitors (BKIs) have been shown to be potent inhibitors of Toxoplasma gondii calcium-dependent protein kinase 1. Pyrazolopyrimidine and 5-aminopyrazole-4-carboxamide scaffold-based BKIs are effective in acute and chronic experimental models of toxoplasmosis. Through further explorati...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Infect Dis
Päätekijät: Hulverson, Matthew A, Bruzual, Igor, McConnell, Erin V, Huang, Wenlin, Vidadala, Rama S R, Choi, Ryan, Arnold, Samuel L M, Whitman, Grant R, McCloskey, Molly C, Barrett, Lynn K, Rivas, Kasey L, Scheele, Suzanne, DeRocher, Amy E, Parsons, Marilyn, Ojo, Kayode K, Maly, Dustin J, Fan, Erkang, Van Voorhis, Wesley C, Doggett, J Stone
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
Major Articles and Brief Reports
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467197/
https://ncbi.nlm.nih.gov/pubmed/30423128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy664
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