Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis

Bumped kinase inhibitors (BKIs) have been shown to be potent inhibitors of Toxoplasma gondii calcium-dependent protein kinase 1. Pyrazolopyrimidine and 5-aminopyrazole-4-carboxamide scaffold-based BKIs are effective in acute and chronic experimental models of toxoplasmosis. Through further explorati...

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Bibliographische Detailangaben
Veröffentlicht in:J Infect Dis
Hauptverfasser: Hulverson, Matthew A, Bruzual, Igor, McConnell, Erin V, Huang, Wenlin, Vidadala, Rama S R, Choi, Ryan, Arnold, Samuel L M, Whitman, Grant R, McCloskey, Molly C, Barrett, Lynn K, Rivas, Kasey L, Scheele, Suzanne, DeRocher, Amy E, Parsons, Marilyn, Ojo, Kayode K, Maly, Dustin J, Fan, Erkang, Van Voorhis, Wesley C, Doggett, J Stone
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467197/
https://ncbi.nlm.nih.gov/pubmed/30423128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy664
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