Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer

Tumor neoantigens arising from somatic mutations in the cancer genome are less likely to be subject to central immune tolerance and are therefore attractive targets for vaccine immunotherapy. We utilized whole-exome sequencing, RNA sequencing (RNASeq), and an in silico immunogenicity prediction algo...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Kinkead, Heather L., Hopkins, Alexander, Lutz, Eric, Wu, Annie A., Yarchoan, Mark, Cruz, Kayla, Woolman, Skylar, Vithayathil, Teena, Glickman, Laura H., Ndubaku, Chudi O., McWhirter, Sarah M., Dubensky, Thomas W., Armstrong, Todd D., Jaffee, Elizabeth M., Zaidi, Neeha
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237485/
https://ncbi.nlm.nih.gov/pubmed/30333318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122857
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