Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer

Tumor neoantigens arising from somatic mutations in the cancer genome are less likely to be subject to central immune tolerance and are therefore attractive targets for vaccine immunotherapy. We utilized whole-exome sequencing, RNA sequencing (RNASeq), and an in silico immunogenicity prediction algo...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:JCI Insight
Κύριοι συγγραφείς: Kinkead, Heather L., Hopkins, Alexander, Lutz, Eric, Wu, Annie A., Yarchoan, Mark, Cruz, Kayla, Woolman, Skylar, Vithayathil, Teena, Glickman, Laura H., Ndubaku, Chudi O., McWhirter, Sarah M., Dubensky, Thomas W., Armstrong, Todd D., Jaffee, Elizabeth M., Zaidi, Neeha
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2018
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237485/
https://ncbi.nlm.nih.gov/pubmed/30333318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122857
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