Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer

Tumor neoantigens arising from somatic mutations in the cancer genome are less likely to be subject to central immune tolerance and are therefore attractive targets for vaccine immunotherapy. We utilized whole-exome sequencing, RNA sequencing (RNASeq), and an in silico immunogenicity prediction algo...

詳細記述

保存先:
書誌詳細
出版年:JCI Insight
主要な著者: Kinkead, Heather L., Hopkins, Alexander, Lutz, Eric, Wu, Annie A., Yarchoan, Mark, Cruz, Kayla, Woolman, Skylar, Vithayathil, Teena, Glickman, Laura H., Ndubaku, Chudi O., McWhirter, Sarah M., Dubensky, Thomas W., Armstrong, Todd D., Jaffee, Elizabeth M., Zaidi, Neeha
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2018
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237485/
https://ncbi.nlm.nih.gov/pubmed/30333318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122857
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