Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer

Tumor neoantigens arising from somatic mutations in the cancer genome are less likely to be subject to central immune tolerance and are therefore attractive targets for vaccine immunotherapy. We utilized whole-exome sequencing, RNA sequencing (RNASeq), and an in silico immunogenicity prediction algo...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Kinkead, Heather L., Hopkins, Alexander, Lutz, Eric, Wu, Annie A., Yarchoan, Mark, Cruz, Kayla, Woolman, Skylar, Vithayathil, Teena, Glickman, Laura H., Ndubaku, Chudi O., McWhirter, Sarah M., Dubensky, Thomas W., Armstrong, Todd D., Jaffee, Elizabeth M., Zaidi, Neeha
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237485/
https://ncbi.nlm.nih.gov/pubmed/30333318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122857
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