Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer

Tumor neoantigens arising from somatic mutations in the cancer genome are less likely to be subject to central immune tolerance and are therefore attractive targets for vaccine immunotherapy. We utilized whole-exome sequencing, RNA sequencing (RNASeq), and an in silico immunogenicity prediction algo...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Kinkead, Heather L., Hopkins, Alexander, Lutz, Eric, Wu, Annie A., Yarchoan, Mark, Cruz, Kayla, Woolman, Skylar, Vithayathil, Teena, Glickman, Laura H., Ndubaku, Chudi O., McWhirter, Sarah M., Dubensky, Thomas W., Armstrong, Todd D., Jaffee, Elizabeth M., Zaidi, Neeha
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237485/
https://ncbi.nlm.nih.gov/pubmed/30333318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122857
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