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Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional addictions that may be therapeutically exploited. Yet, the mechanisms ultimately responsible for these addictions are poorly understood. Here we investigated the transcriptional dependencies of transformed c...

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Τόπος έκδοσης:	Nat Med
Κύριοι συγγραφείς:	Zanconato, Francesca, Battilana, Giusy, Forcato, Mattia, Filippi, Letizia, Azzolin, Luca, Manfrin, Andrea, Quaranta, Erika, Di Biagio, Daniele, Sigismondo, Gianluca, Guzzardo, Vincenza, Lejeune, Pascale, Haendler, Bernard, Krijgsveld, Jeroen, Fassan, Matteo, Bicciato, Silvio, Cordenonsi, Michelangelo, Piccolo, Stefano
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	2018
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6181206/ https://ncbi.nlm.nih.gov/pubmed/30224758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0158-8
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Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

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