Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional addictions that may be therapeutically exploited. Yet, the mechanisms ultimately responsible for these addictions are poorly understood. Here we investigated the transcriptional dependencies of transformed c...

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Publicat a:Nat Med
Autors principals: Zanconato, Francesca, Battilana, Giusy, Forcato, Mattia, Filippi, Letizia, Azzolin, Luca, Manfrin, Andrea, Quaranta, Erika, Di Biagio, Daniele, Sigismondo, Gianluca, Guzzardo, Vincenza, Lejeune, Pascale, Haendler, Bernard, Krijgsveld, Jeroen, Fassan, Matteo, Bicciato, Silvio, Cordenonsi, Michelangelo, Piccolo, Stefano
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181206/
https://ncbi.nlm.nih.gov/pubmed/30224758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0158-8
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