YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

How the behaviour of somatic stem cells (SCs) is influenced by mechanical signals remains a black-box in cell biology. Here we show that YAP/TAZ regulation by cell shape and rigidity of the extracellular matrix (ECM) dictates a pivotal SC decision: to remain undifferentiated and grow, or to activate...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Totaro, Antonio, Castellan, Martina, Battilana, Giusy, Zanconato, Francesca, Azzolin, Luca, Giulitti, Stefano, Cordenonsi, Michelangelo, Piccolo, Stefano
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442321/
https://ncbi.nlm.nih.gov/pubmed/28513598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15206
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