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YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
How the behaviour of somatic stem cells (SCs) is influenced by mechanical signals remains a black-box in cell biology. Here we show that YAP/TAZ regulation by cell shape and rigidity of the extracellular matrix (ECM) dictates a pivotal SC decision: to remain undifferentiated and grow, or to activate...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5442321/ https://ncbi.nlm.nih.gov/pubmed/28513598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15206 |
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