HDAC Inhibition Counteracts Metastatic Re-Activation of Prostate Cancer Cells Induced by Chronic mTOR Suppression

This study was designed to investigate whether epigenetic modulation by histone deacetylase (HDAC) inhibition might circumvent resistance towards the mechanistic target of rapamycin (mTOR) inhibitor temsirolimus in a prostate cancer cell model. Parental (par) and temsirolimus-resistant (res) PC3 pro...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Makarević, Jasmina, Rutz, Jochen, Juengel, Eva, Maxeiner, Sebastian, Mani, Jens, Vallo, Stefan, Tsaur, Igor, Roos, Frederik, Chun, Felix K.-H., Blaheta, Roman A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162415/
https://ncbi.nlm.nih.gov/pubmed/30200497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells7090129
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