HDAC Inhibition Counteracts Metastatic Re-Activation of Prostate Cancer Cells Induced by Chronic mTOR Suppression

This study was designed to investigate whether epigenetic modulation by histone deacetylase (HDAC) inhibition might circumvent resistance towards the mechanistic target of rapamycin (mTOR) inhibitor temsirolimus in a prostate cancer cell model. Parental (par) and temsirolimus-resistant (res) PC3 pro...

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Publicado en:Cells
Main Authors: Makarević, Jasmina, Rutz, Jochen, Juengel, Eva, Maxeiner, Sebastian, Mani, Jens, Vallo, Stefan, Tsaur, Igor, Roos, Frederik, Chun, Felix K.-H., Blaheta, Roman A.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162415/
https://ncbi.nlm.nih.gov/pubmed/30200497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells7090129
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