HDAC Inhibition Counteracts Metastatic Re-Activation of Prostate Cancer Cells Induced by Chronic mTOR Suppression

This study was designed to investigate whether epigenetic modulation by histone deacetylase (HDAC) inhibition might circumvent resistance towards the mechanistic target of rapamycin (mTOR) inhibitor temsirolimus in a prostate cancer cell model. Parental (par) and temsirolimus-resistant (res) PC3 pro...

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Pubblicato in:Cells
Autori principali: Makarević, Jasmina, Rutz, Jochen, Juengel, Eva, Maxeiner, Sebastian, Mani, Jens, Vallo, Stefan, Tsaur, Igor, Roos, Frederik, Chun, Felix K.-H., Blaheta, Roman A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162415/
https://ncbi.nlm.nih.gov/pubmed/30200497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells7090129
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