Resistance to the mTOR Inhibitor Temsirolimus Alters Adhesion and Migration Behavior of Renal Cell Carcinoma Cells through an Integrin α5– and Integrin β3–Dependent Mechanism()()

Inhibitors of the mammalian target of rapamycin (mTOR) have improved the treatment of renal cell carcinoma (RCC). However, chronic drug exposure may trigger resistance, limiting the utility of these agents. The metastatic behavior of RCC cells, susceptible (RCC(par)) or resistant (RCC(res)) to the m...

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Hauptverfasser: Juengel, Eva, Makarević, Jasmina, Reiter, Michael, Mani, Jens, Tsaur, Igor, Bartsch, Georg, Haferkamp, Axel, Blaheta, Roman A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094828/
https://ncbi.nlm.nih.gov/pubmed/24862756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.03.011
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