Resistance to the mTOR Inhibitor Temsirolimus Alters Adhesion and Migration Behavior of Renal Cell Carcinoma Cells through an Integrin α5– and Integrin β3–Dependent Mechanism()()

Inhibitors of the mammalian target of rapamycin (mTOR) have improved the treatment of renal cell carcinoma (RCC). However, chronic drug exposure may trigger resistance, limiting the utility of these agents. The metastatic behavior of RCC cells, susceptible (RCC(par)) or resistant (RCC(res)) to the m...

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Autors principals: Juengel, Eva, Makarević, Jasmina, Reiter, Michael, Mani, Jens, Tsaur, Igor, Bartsch, Georg, Haferkamp, Axel, Blaheta, Roman A.
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094828/
https://ncbi.nlm.nih.gov/pubmed/24862756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.03.011
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