Influence of the HDAC Inhibitor Valproic Acid on the Growth and Proliferation of Temsirolimus-Resistant Prostate Cancer Cells In Vitro

The mechanistic target of rapamycin (mTOR) is elevated in prostate cancer, making this protein attractive for tumor treatment. Unfortunately, resistance towards mTOR inhibitors develops and the tumor becomes reactivated. We determined whether epigenetic modulation by the histone deacetylase (HDAC) i...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Makarević, Jasmina, Rutz, Jochen, Juengel, Eva, Maxeiner, Sebastian, Tsaur, Igor, Chun, Felix K.-H., Bereiter-Hahn, Jürgen, Blaheta, Roman A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520872/
https://ncbi.nlm.nih.gov/pubmed/31010254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11040566
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