Acquired resistance to temsirolimus is associated with integrin α7 driven chemotactic activity of renal cell carcinoma in vitro

The mechanistic target of the rapamycin (mTOR) inhibitor, temsirolimus, has significantly improved the outcome of patients with renal cell carcinoma (RCC). However, development of temsirolimus-resistance limits its effect and metastatic progression subsequently recurs. Since integrin α7 (ITGA7) is s...

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Vydáno v:Oncotarget
Hlavní autoři: Engl, Tobias, Rutz, Jochen, Maxeiner, Sebastian, Fanguen, Sorel, Juengel, Eva, Koschade, Sebastian, Roos, Frederik, Khoder, Wael, Tsaur, Igor, Blaheta, Roman A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922352/
https://ncbi.nlm.nih.gov/pubmed/29721158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24650
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