Acquired resistance to temsirolimus is associated with integrin α7 driven chemotactic activity of renal cell carcinoma in vitro

The mechanistic target of the rapamycin (mTOR) inhibitor, temsirolimus, has significantly improved the outcome of patients with renal cell carcinoma (RCC). However, development of temsirolimus-resistance limits its effect and metastatic progression subsequently recurs. Since integrin α7 (ITGA7) is s...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Engl, Tobias, Rutz, Jochen, Maxeiner, Sebastian, Fanguen, Sorel, Juengel, Eva, Koschade, Sebastian, Roos, Frederik, Khoder, Wael, Tsaur, Igor, Blaheta, Roman A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922352/
https://ncbi.nlm.nih.gov/pubmed/29721158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24650
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