Influence of the HDAC Inhibitor Valproic Acid on the Growth and Proliferation of Temsirolimus-Resistant Prostate Cancer Cells In Vitro

The mechanistic target of rapamycin (mTOR) is elevated in prostate cancer, making this protein attractive for tumor treatment. Unfortunately, resistance towards mTOR inhibitors develops and the tumor becomes reactivated. We determined whether epigenetic modulation by the histone deacetylase (HDAC) i...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancers (Basel)
Auteurs principaux: Makarević, Jasmina, Rutz, Jochen, Juengel, Eva, Maxeiner, Sebastian, Tsaur, Igor, Chun, Felix K.-H., Bereiter-Hahn, Jürgen, Blaheta, Roman A.
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520872/
https://ncbi.nlm.nih.gov/pubmed/31010254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11040566
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