SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement

The entry of human immunodeficiency virus into host cells is mediated by the envelope glycoprotein (Env) trimeric spike, which consists of three exterior gp120 subunits and three transmembrane gp41 subunits. The trimeric Env undergoes extensive conformational rearrangement upon interaction with the...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Alsahafi, Nirmin, Anand, Sai Priya, Castillo-Menendez, Luis, Verly, Myriam Maude, Medjahed, Halima, Prévost, Jérémie, Herschhorn, Alon, Richard, Jonathan, Schön, Arne, Melillo, Bruno, Freire, Ernesto, Smith, Amos B., Sodroski, Joseph, Finzi, Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146791/
https://ncbi.nlm.nih.gov/pubmed/30021898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01080-18
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