Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors

Interactions between the gp120 and gp41 subunits of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer maintain the metastable unliganded form of the viral spike. Binding of gp120 to the receptor, CD4, changes the Env conformation to promote gp120 interaction with the...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Virol
मुख्य लेखकों: Pacheco, Beatriz, Alsahafi, Nirmin, Debbeche, Olfa, Prévost, Jérémie, Ding, Shilei, Chapleau, Jean-Philippe, Herschhorn, Alon, Madani, Navid, Princiotto, Amy, Melillo, Bruno, Gu, Christopher, Zeng, Xin, Mao, Youdong, Smith, Amos B., Sodroski, Joseph, Finzi, Andrés
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2017
विषय:
Pathogenesis and Immunity
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309946/
https://ncbi.nlm.nih.gov/pubmed/28003492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02219-16
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