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Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors

Interactions between the gp120 and gp41 subunits of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer maintain the metastable unliganded form of the viral spike. Binding of gp120 to the receptor, CD4, changes the Env conformation to promote gp120 interaction with the...

詳細記述

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書誌詳細
出版年:J Virol
主要な著者: Pacheco, Beatriz, Alsahafi, Nirmin, Debbeche, Olfa, Prévost, Jérémie, Ding, Shilei, Chapleau, Jean-Philippe, Herschhorn, Alon, Madani, Navid, Princiotto, Amy, Melillo, Bruno, Gu, Christopher, Zeng, Xin, Mao, Youdong, Smith, Amos B., Sodroski, Joseph, Finzi, Andrés
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309946/
https://ncbi.nlm.nih.gov/pubmed/28003492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02219-16
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