Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors

Interactions between the gp120 and gp41 subunits of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer maintain the metastable unliganded form of the viral spike. Binding of gp120 to the receptor, CD4, changes the Env conformation to promote gp120 interaction with the...

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Udgivet i:J Virol
Main Authors: Pacheco, Beatriz, Alsahafi, Nirmin, Debbeche, Olfa, Prévost, Jérémie, Ding, Shilei, Chapleau, Jean-Philippe, Herschhorn, Alon, Madani, Navid, Princiotto, Amy, Melillo, Bruno, Gu, Christopher, Zeng, Xin, Mao, Youdong, Smith, Amos B., Sodroski, Joseph, Finzi, Andrés
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309946/
https://ncbi.nlm.nih.gov/pubmed/28003492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02219-16
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