The Highly Conserved Layer-3 Component of the HIV-1 gp120 Inner Domain Is Critical for CD4-Required Conformational Transitions

The trimeric envelope glycoprotein (Env) of human immunodeficiency virus type 1 (HIV-1) mediates virus entry into host cells. CD4 engagement with the gp120 exterior envelope glycoprotein subunit represents the first step during HIV-1 entry. CD4-induced conformational changes in the gp120 inner domai...

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Detalhes bibliográficos
Main Authors: Désormeaux, Anik, Coutu, Mathieu, Medjahed, Halima, Pacheco, Beatriz, Herschhorn, Alon, Gu, Christopher, Xiang, Shi-Hua, Mao, Youdong, Sodroski, Joseph, Finzi, Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571356/
https://ncbi.nlm.nih.gov/pubmed/23255784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03104-12
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